Ethics Leadership Comparison Matrix Paper - 1272 Words

Comparison Matrix Paper Ethics Leadership Jennifer M. Howard Grand Canyon University: LDR 800 February 22, 2012 INTRODUCTION This paper compares three empirical articles about ethical leadership practices that relate to the use of ethical power, authority, persuasion, and/or motivation. Article one was entitled â€Å"The relationship between ethical leadership and core job characteristics† and written by Ronald F. Piccolo, Rebecca Greenbaum, Deanne N. Den Hartog, and Robert Folger (2010). The second article was entitled â€Å"Impact of Ethical Leadership and Leader-Member Exchange on Whistle Blowing:†¦show more content†¦Article one participants were 174 junior and senior level undergraduate students and 107 masters of business education students from a large southeastern university in the United States. Article two consisted on 81 students from different postgraduate programs of a top engineering institute in India. Article three consisted of 191 working adults with a large university. Results of study The results of the articles were different. Article one resu lt showed that ethical leadership had a positive effect on follower effort and was mediated by task significance. The results also showed the relationship between subordinates’ job performance and ethical leadership was mediated by effort and task significance. The results of article two showed that whistle blowing is impacted strongly by ethical leadership behavior. Results showed that moral intensity of issues was moderated by the relationship between leader-member exchange (LMX) and ethical leadership as related to whistle blowing. Article three results found that deviance was negatively related to ethical leadership while follower organizational behaviors (OCB) were positively related to ethical leadership and were moderated by follower self-esteem. The results also found that ethical leadership should be used as a method to enhance citizenship and promote follower citizenship behaviors. The result also showed that the relationship between OCB, deviantShow MoreRelatedEval uating Greenby Education Department1538 Words   |  7 PagesaRunning head: EVALUATION RESEARCH PAPER Case 10: Evaluating the Consultation and Education Department Research University of Phoenix Evaluation the Consultation and Education Department The Greenby Community Mental Health Center process evaluation measure suggests the Consultation and Education Department needs to implement the address of the real questionable issue within the organization, and to evaluate the programs being offered through the organization. The questionable issueRead MorePestel Analysis on Motor Industry10196 Words   |  41 Pagesthought to help alleviate and categorise this problem but this approach lacks a comparison of the models found in industry e.g. BCG, 7S McKinsey, ANSOFF etc. Consequently at academic level (but not only) we see models like P5F, etc. predominate while tools like SWOT, PEST, ARC etc. populate the consultancy arena and operative levels of the organisation. The purpose of this paper is therefore to provide an overview and comparison of selected models used in the development of business strategy together withRead MoreLeadership Is Unleashing And Wisely Guiding Energy Towards Meaningful, Long Lasting Results3057 Words   |à ‚  13 Pages Part A – Question 1a ‘Leadership is unleashing and wisely guiding energy towards meaningful, long lasting results.’ Whilst the definition may appear quite simplistic, in my opinion it’s a fairly succinct definition of leadership, however it does lack some of the attributes of what is good leadership. Within the course we learnt a multitude of aspects about the concept of leadership. We learnt about the types of leadership styles, the traits of a good leader and the importance of strategyRead MoreAcca P3 Revision Notes5881 Words   |  24 Pagescover the whole of the ACCA P3 syllabus  ©Darren Sparkes, 2010 1 Contents Page no. Paper 3 Examiners Approach†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦.... 3 Extracts from the Examiners report †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦...4 Examination Technique†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦..†¦Ã¢â‚¬ ¦..7 Background and examination format..†¦............9 Syllabus Overview†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦...........10 Strategic Planning†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦...†¦.....11 Mission and Objectives†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦12 Business Professional Ethics..†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦...13 Internal Analysis†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..†¦14 External Analysis†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦....15 StrategicRead MoreThe Role Of External Factors Affecting An Organization3292 Words   |  14 Pageswork. Some of these have power of b lock or advance or some of them are interested in what organisation do. One method you can use to give position them on matrix and which indicating relevant affect and importance. This matrix can also be used in monitoring tool during implementation. Organisation can give the priority according to this matrix or map: †¢ People with high power and high interest must fully engage and must great effort to satisfy them. †¢ People with high power and less interest requireRead MoreThe Role Of External Factors Affecting An Organization3291 Words   |  14 Pageswork. Some of these have power of block or advance or some of them are interested in what organisation do. One method you can use to give position them on matrix and which indicating relevant affect and importance. This matrix can also be used in monitoring tool during implementation. Organisation can give the priority according to this matrix or map: †¢ People with high power and high interest must fully engage and must great effort to satisfy them. †¢ People with high power and less interest requireRead MoreEssay on Orion Shield Project5524 Words   |  23 Pagespersonnel, materials and supplies, and methods of communication in order to successfully complete a project. Unfortunately, these basic methods of project management were not used by Scientific Engineering Corporation in the Orion Shield Project. This paper has compared Scientific Engineering Corporation’s (SEC) project management techniques to the nine project management knowledge areas as outlined in the Project Management Book of Knowledge (PMBOK) 4th ed., 2008. According to PMBOK (2008), there areRead MoreHmpyc80 Research Methodology3369 Words   |  14 PagesParadigms (p.86)- Positivism Triangulation /Observation / Interviews / Bracketing Ethics TOPIC 5 PAST EXAM PAPER- OCT NOV 2011 (4 SESSIONS TO COVER) TOPIC 6 Revision- 1-2 sessions in October ETHICS AND TOPIC SELECTION Type of research you should avoid for your honours project Try to avoid the following research topics and methods unless you have ethical approval (that is if your project has been approved by an ethics committee in the place where you plan to conduct your study, or if your projectRead MoreDefinition Of Scientific Management Theory Essay6042 Words   |  25 PagesFayol, and others like him, are responsible for building the foundations of modern management theory. Moreover, there are some important components of scientific management which include analysis, synthesis, efficiency, empiricism, rationality, work ethic, elimination of waste and standardized best practices. 1.1 Four principal of Scientific Management Find the one BEST WAY of doing the tasks of your subordinates. This first principle says that we should change the techniques of doing work otherwiseRead MoreManagement and Mcd2040 Managing People6266 Words   |  26 Pagesincluding stakeholder interests, ethics and social responsibility apply the skills of academic writing, research, questioning and analysis required of the management discipline. Unit structure This unit covers the following topics: 1. Introduction to Organisations and Managers 2. Management Yesterday and Today 3. Understanding and doing academic research, writing and referencing 4. The external environment 5. The internal environment 6. Social responsibility, managerial ethics and sustainable management

How We Market your Products Free Essays

Our vision is that every business and organization will eventually have a web site to market their company, products, and services. Users will migrate from the off-line yellow pages to the web to find and contact local businesses. Current online search tools do a good job of indexing the web, but finding location-specific businesses is haphazard and inaccurate. We will write a custom essay sample on How We Market your Products or any similar topic only for you Order Now We focus on cataloging every business and organization web site into a single commercial database so that users can quickly and easily find local, national, or global businesses online. 1. Become the definitive source for listing displaying business organization web site information. Similar to the off-line yellow pages, we want to be the single source of information about every commercial web site and keep it the most current and up-to-date. 2. Instead of becoming a destination site, we deliver our robust database to navigation sites (search engines directories), media companies, local portals government sites, and any other web property that want to help their users find a complete source of business web sites in one spot. 3. Help manage the navigation tools at the smaller sites by delivering navigation data and allowing them to outsource their search engine content maintenance to create a network of smaller portals that share navigation content and resources. We have developed technology to spider the web and categorize database commerical sites. The technology is similar to a search engine spider in that it gathers the URL and description of sites by following links. But we use a process that assigns each link to one of our 15,000 yellow-pages type categories by using specific keywords and comparing where it is categorized in other online databases. Also, our spider gathers business contact information, such as address, phone numbers, and email information. This allows us to follow-up our efforts with a direct contact to each business to ensure their listing information and category is correct. Our active technique ensures we gather 5 times more web sites in each category than the average online directory maintains. By categorizing each listing and recording the contact data, we provide much-needed â€Å"periphery† for the web: our technique allows the user to see all of the particular businesses in a particular geographic location. It is a cross between the yellow pages and an online search engine of web sites. The process of updating our data is one the most robust on the web. First our spider revisits each site at least once every quarter to verify the information. Unlike other services software that just check if a link is â€Å"live,† we can tell if the site is under contraction, or the domain name is for sale, or other signs that the business is unavailable although the link remains active. More importantly, we e-mail the business at least once a year for changes, and reward companies that respond with a higher ranking. This gives us a good repsonse rate and ensures a proactive interest from each company to keep their data up-to-date. The primary targets are those established portal and navigation sites online that have a need to deliver this content. These include: Web-based directories and search engines, such as yahoo, excite, lycos Business directories and smaller search portals Industry-related sites portals (apparel.net, lawyers.com, etc.) Media sites (newspapers, television stations, radio) Direct mail services mailing list providers Content providers other infomediaries Together I have databased 500,000 web sites so far, and many of them are businesses in these categories. Each listing includes a link, business name, address, phone numbers, and email. For our meeting next week, I will provide an Access database of all the companies I have categorized in these fields. I want to see if there is a need for my product in any of the markets that I†ve described above. My biggest concern is finding a market for the product I†ve developed, and these questions might help answer that. What is their biggest need in terms of their site? Do they maintain a listing of links to web sites relating to their field? How do they add new information and keep existing information current? How much time and money is spent on managing this data? Would they be willing to share this data with us, in return for receiving the information shared by other sites in our network? If we could save them time and money, would they be willing to outsource the management and upkeep of this information? Do they have a need for the type of data we†ve gathered and services we provide? Do they think their users would benefit from being able to find a complete listing of other web sites related to their subject matter? Would they be willing to pay to use our current and complete database at their site? Who else would be willing to use this data? What other types of businesses have I†ve missed? For an example to goal #3 above, it takes a lot of time energy for a local portal to gather the links of businesses in their area. They only catch the ones that are submitted to them, or the ones they find using their human editors. Likewise, a site focusing on the apparel industry can use a lot of energy effort to record and display links to clothing fashion sites in its industry. On the maintenance side, it can be time consuming to categorize their listings, check them to make sure they are current, and modify/delete old dead links. We want to partner with each site and provide the infomediary to exchange data: since they both share data with Speedy Pete†s database, they have access to not only our spider†s adds, but the other site†s listings, as well. The local portal may have listings related to the clothing industry that the apparel portal does not have and vice versa. We keep the data current and updated using our technology, and deliver a robust database of â€Å"shared† navigation data to each site. How to cite How We Market your Products, Essay examples

Eutahnasia Essay Example For Students

Eutahnasia Essay Euthanasia is an issue that has been debated on many occasions. Both ethical and political questions have been raised. It is the one issue that can touch anyone, even politicians. Euthanasia is an issue that is controversial from all sides and is such a deeply felt issue across society. Parliament has a duty to address euthanasia. Terminally ill patients should have the opportunity of having doctor-assisted suicide or euthanasia as a legal option. Euthanasia should be legal so patients can die with dignity. It’s their right to choose when they want to die, and caring for such a terminally ill family member becomes a burden to the rest of the family. Many terminally ill sufferers want to have the choice to die with dignity and pride. By doing so they feel a sense of happiness that their suffering is over. Death with dignity basically means dying while still having some self-respect. Euthanasia is better then seeing patients not eating or drinking, consuming large amounts of pai nkillers and essentially being allowed to slip away. Patients also feel a sense of worth and importance in the society. Euthanasia has the potential to effect each and everyone of use; therefore, we have the right to choose how and when we want to die. One has to ask themselves if they were in the condition where they could not bathe, they could not go to the washroom, where they knew death was around the corner and the only thing keeping them alive was drugs, what would they do? If one cannot give consent to their death then whose body is it? Who owns their life? The decision is left up the Parliament who cannot feel what the patient is going through, how they are suffering, and their agony.Victims of a deadly virus have the necessary means to leave when they are ready and should not be faced with any higher authority telling them that it is against the law. Patients feel lose of control over their lives. Having a family member on their deathbed at times can become a burden on them . They could transfer them to an institution, however, that can prompt an ill person to take their life alone. When terminally ill patients can not take matters into their own hands, it places an agonising responsibility on the shoulders of the family. Family members should not be forced to choose between respecting the wishes of a loved one and obeying the law. Family members are motivated solely by their love and compassion for whom ever is ill and the need, at least in their mind, is that they should not suffer any more pain. Euthanasia is like a compassionate homicide. When one takes their own life, they are hurting no one but yet they are taking away all the pain they have suffered. Terminally ill patients fear the fact of being alive but not really living, mentally. Providing euthanasia as a legal option allows patients to die with dignity, to have the right to die, and to lessen the burden on family members. Euthanasia is such a great, debatable topic and will remain on the public agenda until finally resolved. Bibliography:

Sartre`s Existentialism Essays - Philosophy, French People

Sartre`s Existentialism Jean-Paul Sartre . . . the name is one of the most popular in modern philosophy. But who was he? What did he write and what were his works about? What was his role with regard to Existentialism? What is Existentialism, really? What life influences affected the person as whom he became famous? How would Sartre assess various social topics that we face today? What are the problems with Sartre's view of Existentialism and existence in general? These are the questions addressed in the following pages of this brief dissertation. His life Upon reviewing several sources, it is apparent that Sartre was a very disorganized and inconsistent individual. Sartre was obsessed with his intellect to the point of abandon of all else in his life - personal hygiene, honesty, organization, thoroughness, and more. It seems that he felt he was of superior intelligence in comparison to all others who surrounded him. He was not necessarily a great and original thinker, but rather a superb media sensation of sorts. Rather than developing Existentialist thought, he merely promoted it to amazing popularity through his eccentric lifestyle. Although he is best known for his association with Existentialism, it is interesting to note that he denounced its principles later in life and adopted Marxism, which he also later denounced. Jean-Paul-Charles-Aymard Sartre was born in Paris on June 21, 1905, the only child of Anne-Marie Schweitzer Sartre and Jean-Baptiste Sartre. Anne-Marie was the first cousin of Albert Schweitzer, the famed Nobel Peace Prize recipient, and the daughter of Karl Schweitzer, who had published texts on religion, philosophy, and languages. Jean-Baptiste was the son of Eymard Sartre, a doctor who had written several medical texts. Although his philosophy would deny it, it may have been fated that Jean-Paul would himself become a famous writer; it was in his genes. Jean-Baptiste and Anne-Marie were deeply in love. They married on May 5, 1904. Jean-Baptiste was enlisted in the French Navy and was away on an assignment when Jean-Paul was born 13 months later. Sadly, hardly more than a year after the birth of their son, Jean-Baptiste had returned home from China in November only to fall ill in March and die on September 17, 1906. After the death of Jean-Baptiste, Anne-Marie moved herself and her young son into her father's house, the Schweitzer home. Karl Schweitzer was a strict and domineering man and the year the two spent living there affected Sartre's life forever. His mother kept his hair long and dressed him in effeminate clothing, probably as a means of escaping the oppressive nature of her father. Schweitzer, however, disgusted by the child's appearance, took him to the barber one day and had his hair cut. Jean-Paul's ugliness then became apparent. Without the cloak of long hair and frilly clothes, his short stature, one eye that looked askance (from a juvenile illness), and awkward appearance were undeniable, even to his mother. He was ostracized by other children for his appearance. He was an outcast. At the age of eight he began to write scripts when he received puppets from his mom. Children tolerated him in order to be entertained by his shows. He basked in the attention. He began a pattern of outrageous behavior that it seems he believed would earn him popularity. Apparently it worked. In October of 1913, Eymard Sartre died and Jean-Paul fell under near complete control of the Schweitzers. When war broke out in 1914, it fascinated Sartre, and he wrote some short stories about it. In 1915 Jean-Paul was enrolled at Lycee Henri IV, a highly regarded school. Here he found children he could relate to: intellectually stimulating and of his class level, children who could respect him for himself. Yet, even at this early age, it was apparent to his teachers that Jean-Paul did not hone any of his thoughts; his intelligence was apparent, but he merely skimmed over many subjects without delving into any in depth. His mother remarried when he was twelve, to the apparent disapproval of Jean-Paul. The new family moved to LaRochelle in 1917, but after Sartre got into trouble on several occasions, he was returned to Lycee Henri IV where he was a boarding student. At this time he became close with Paul-Yves Nizan, a quiet and shy boy of considerable intellect. Where Sartre was disorganized, slovenly, and incomplete, Nizan was orderly, stylish, and thorough. Nizan was prone to fits of depression and drinking, to the fascination of Sartre. The two were nearly inseparable throughout college and beyond. In 1922 the two enrolled

Writing Step by Step Winning Resume

Writing Step by Step Winning Resume Writing Step by Step: Winning Resume Want to be on the competitive edge and get the job of your dreams? Writing step by step will help you compose a job-winning resume! Follow these recommendations, discover useful tips, and use them to make a great CV! Step 1. Decide what kind of job you are looking for and determine whether your skills are suitable for it. Step 2. Make sure your resume has a clear structure. Divide it into the following parts: objective, personal details, education, work experience, skills, foreign languages, hobbies and interests, references. Step 3. Complete each part with suitable information. Â  Objective is one of key parts of your CV. Formulate the exact goal for your job search and professional intentions. The way you express why you want to get this or that job is likely to make the HR Manager choose your candidacy and invite you to the interview. Â  Personal Details come into play in the next part of your CV, where you actually introduce yourself. Provide personal information: first and last name, date and place of birth, age, address, telephone number and e-mail. If you have more than one phone number, provide all of them. In case one number doesn’t answer, the recruiter can get in touch with you by using another one. The Education section is designed to provide details on your qualifications, including any and all degrees you have earned. Its also a good idea to mention training courses you have attended. Doing so may indicate that you take a serious interest in some specific area and want to increase your academic achievements. Well-rounded education and high qualifications – thats what recruiters seek! In the next part that is called Work Experience, list all the companies you worked for, as well as your positions and responsibilities. Dont be afraid to mention the smallest companies and the lowest positions. Everyone needs a start! Besides, starting in lower positions or working for smaller companies can mean that you have a more thorough knowledge of all areas in your specialty. Your desire to move on and get essential experience speaks in favor of your candidacy! The section labeled Skills has to include information regarding all abilities you consider to be relevant for the targeted job and position. Interpersonal, leadership and organizational skills, team spirit, willingness to compromise – each can be vital to your new job! Are you creative and enthusiastic – write a couple of words about that, too! Have a critical look at yourself – dont exaggerate or understate your weak points, but at the same time, theres no need to underestimate yourself. Remember that you are not cheap labor but, instead, a promising employee! What does the part Foreign Languages have to do with anything? If the company is an international one and has business partners in other countries, your ability to provide successful communication in other languages can be of great importance. State what languages you speak fluently or in which you have a good written command. Do you have a bright personality? Say a couple of words about it in the section under Hobbies and Interests! Show that you are not only a book worm or that you surf the Internet all day long. Tell briefly about other parts of your life that are exciting and engaging! In References name two or three people who can recommend you and confirm your personal characteristics as well as qualifications. State their positions and provide telephone numbers so that the recruiter can contact them as needed. Step 4. Attach a nice photo of yourself. Very often applicants ignore this request. However, to a highly-qualified HR Manager it means that either the applicant doesnt take the job advertisement seriously or doesnt know how. Regarding the photo itself, it shouldnt be too formal or vice-versa, too frivolous. Choose one where you are in a good mood, look friendly and are properly dressed. The picture you choose should say that you are easy to deal with and serious enough to work diligently. Step 5. Place your resume on websites that specialize in recruitment. A properly composed resume will draw the attention of an HR manager and will help you get the job! Develop a resume and become a successful job candidate! Good luck with getting a good job! Otherwise, you can visit our writing company and order a custom resume of any complexity.

How to Know If Youve Got Fire Ants

How to Know If You've Got Fire Ants Red imported fire ants defend their nests aggressively and can sting repeatedly. Their venom causes a severe burning and itching sensation, and in rare cases, may trigger a life-threatening allergic reaction. Red imported fire ants can put people and pets at risk for stings, and impact wildlife populations. If youve got fire ants, you may need to treat your property to eliminate them. Before you rush out for some fire ant killer, though, you should be sure youve got fire ants. Ants play an important role in the ecosystem, and you dont want to kill the wrong kind. To identify red imported fire ants, look at three things: their physical features, the ant nest, and the way the ants behave. Differentiating Fire Ants from Other Ant Species Look for the following traits to identify red imported fire ants: Nodes: Fire ants, whether native or imported, have two nodes at the constricted waist between the thorax and abdomen.Antennal clubs: The antennae of fire ants (genus Solenopsis) consist of 10 segments, with a two-segment club.Small size: Red imported fire ant workers measure just 1.5 mm to 4 mm.Size variation: Red imported fire ant workers vary in size according to caste.Color: Red imported fire ants are reddish brown, and the abdomen is darker than the rest of the body.Standard proportion: The heads of red imported fire ants will never be wider than their abdomens in any worker caste. It can be difficult to differentiate red imported fire ants from native fire ant species. We recommend collecting several ants from a suspected fire ant colony and taking them to your local extension office for confirmation. Identifying Red Imported Fire Ant Nests Fire ants live underground, in tunnels and chambers which they construct. When conditions are right for breeding, they expand their nests above ground. Looking at the construction of these mounds can help you identify red imported fire ant nests. Imported fire ant mounds tend to be constructed of loose, crumbly soil. They resemble the piles left behind by digging gophers.Mounds usually appear in spring or fall, or after cool, wet weather when breeding conditions are best.Unlike those of native ants, red imported fire ant mounds do not have an opening in the center. The ants enter the mound from tunnels below ground level.Red imported fire ant mounds usually measure up to 18 in diameter, but will often be considerably smaller.Fire ants build mounds in open, sunny locations.When the mound is disturbed, the white brood will be visible. The larvae and pupae may look like grains of white rice in the soil. Fire Ant Behavior Fire ants are the hotheads of the ant world. You may be able to identify fire ants by observing their behavior. Fire ants defend their nests aggressively. Any disturbance of the nest will elicit a quick response, with dozens of fire ant workers storming from the nest to do battle.Fire ants will typically climb vertical surfaces when disturbed. Look for fire ant workers on tall grasses or other surfaces around the mound. Of course, one sure fire way to find out if theyre fire ants or not is to get stung (not recommended)! Fire ant venom causes an intense burning sensation. Within 24-28 days, the sting sites will form white pustules. If youve been stung by fire ants, youll know it.

Summary of the Article - Government and Poverty Research Paper

Summary of the Article - Government and Poverty - Research Paper Example In the scenario, the author also makes a mention of the more recent American Recovery and Reinvestment Act. The author defines poverty as the dearth of the necessary resources that enable the people to meet their basic needs and extends the commensurate statistics regarding the urban, suburban and rural incidence of poverty. The author does support the extension of government aid to the deserving, while taciturnly mentioning that many people suffer from poverty because they are lazy. The writer also blames the indulgence in substance abuse like tobacco and alcohol as the reason as to why the poor remain poor. Yet, the writer again contradicts one’s assertion by saying that a great number of the poor receiving the government aid do tend to be employed. In the end, the writer conclusively asserts that the government should spend money on imparting skills and education to the poor, rather than wasting the taxpayers’ money on extending nutrition, health and housing. Overall the approach of the writer seems to be discernible against the government funding of the poverty alleviation programs. The poor tend to remain poor because they simply do not have a place in the national financial chain and many times, as said by the author, they lack the skills, education and connections to be able to fit into the national financial dynamics. Hence the government spending on the poverty alleviation programs is the most efficient way to make way for the allocation of the national wealth in favor of the impoverished segments of the society. The government has a self-interest in doing so in the sense that allowing the poverty to rise beyond a certain limit could lead to an unstable society marred by political unrest and crime (Lal & Myint 8). It is rightly said that the hungry minds are angry minds. Hence, state expenditure in poverty alleviation programs allows the government to channelize the skills, abilities and energy of poor sections of the society towards self-development and nation-building. State sponsoring of the poverty alleviation programs is not a choice but an important n ecessity and requisite. Hence, there is no scope or possibility for casting doubts on the relevance or necessity of the government spending on the poor or poverty alleviation programs. The writer himself conveyed that a majority of the poor people receiving government help does have jobs and they tend to work. Hence, the tongue in cheek assertion that the poor people are poor because they happen to be lazy is utterly nonsensical and biased. Poor people, in fact, happen to be poor because they do not have a say in the national and international policy-making procedures and frameworks, where they could chalk out the apt policies that would help them have a share in the process of wealth generation and allocation (Global Issues 1).

Written report of Ma Wan Essay Example | Topics and Well Written Essays - 1250 words

Written report of Ma Wan - Essay Example Although Ma Wan is a small island, it has proved to be a favourable destination for international and local tourists (Sewell & James, 1995). It has a number of leisure places such as the Ma Wan Park, Noah’s Ark Museum, Ma Wan Tung Wan Beach overseen by the Leisure and Cultural Services Department and the Heritage Centre (Sewell & James, 1995). Ma Wan is an island and a relative small one and as such has a small number of inhabitants. One thing notable is the old abandoned houses that are found in sections of the island. The governments seem to have prompted an agenda of relocating some of the locals to ease population in this area. The reduction of the population had fallen to 800 in 2008 (You Lin Xu, 2011). Abandoned shops are visible, and schools too, one being the Kei Wai Primary School indicating that the locals had not been alienated to the outside world. Religion integration is well-bonded in Ma Wan. Noah’s Ark is also an important landmark in Ma Wan. It is based on the Biblical story about Noah. The presence of temples has been an indication of the preservation of Ma Wan’s religion. Presence of churches and temples places Ma Wan as a multi-religion region, and there has been a peaceful co-existence between these different groups. These indicates an important aspect of diversification around Ma Wan. Ma Wan transport has been significantly advanced, and the construction of Kap Shui Mun Bridge is an indication of this progress. However, though, the people of Ma Wan depend on water transport mainly to get to the mainland and also the tourists mainly use water transport as part of their leisure activities. Therefore, it is an indication that Ma Wan has limited connection of roads to the mainland of Hong Kong. As such, the locals offer transport services through boats. A harbour is also present in Ma Wan, and this has been as a result of the evacuation

E-commerce innovation Essay Example for Free

E-commerce innovation Essay Abstract The 21st century has been an era of technological development. Life has been a huge success it is possible to get almost anything that you want. Business done through the aid of an internet is called electronic commerce. This kind of business has boomed in the 21st century with the massive availability of personal computers and laptops. Anyone who has been into shopping online will not miss e-bay. E-bay is one shopping center online that has recently been a favorite of those who loves to do shopping without a hassle. E-bay has been in the business for twelve years. This study embark upon the organizational framework of e-bay that aid them in generating more than they have imagined and the organizational strategies of e-bay. Anyone who gets into business has only one thing in mind, success. Success for one business depends on a lot of factors. Apart from its product, the management and the team behind it matters most. This holds true especially for the e-commerce business because this needs a lot of effort on the part of the management to make it appealing to online customers and to make it worthy of trust of many to believe and give their credit card numbers and trust it with money matters. eBay offers more than just a place for auction; they have numerous programs that cater to the need of its client. E-bay has not only conquered North America but also Asia and Europe. The analysis of the organizational strategies of e-bay was done by doing a content analysis of the documents released regarding their system of management. Introduction The 21st century has been an era of technological development. Life has been a huge success it is possible to get almost anything that you want. Development has been continuous and this is not going to stop. Each tries to adapt to the changes that happens in his life and he has to deal with it. Everything happens in the internet, anything that one could think of. There is internet shopping, online education and internet banking and so many more. Since the time internet came into being; information gathering has never been easy. Nowadays, we can get all information that we need with just one snap of the finger. Name the service that you want and the internet has it. You need to study? The web has a site for online education. Need help on money matters? There’s online banking. You would like to shop but have no time to stand up from your work? Even shopping can be done online. Doing business online is termed as e-commerce or e-business. Examples of internet websites that cater to e-commerce business would be commercial sites like Amazon.com, Buy.com, and eBay (Sharpened, 2002). Within these sites, one could do online shopping. Business done through the aid of an internet is called electronic commerce. This kind of business has boomed in the 21st century with the massive availability of personal computers and laptops. Forrester research has recorded total of $12.2 billion sales in 2003 contributed by e-commerce industry (Wikipedia). E-commerce was introduce in the seventies and has evolved in its use since. In the seventies it was only use for transferring of funds and data electronically to aid companies. Then in the eighties the growth of automated teller machines and online banking was because of e-commerce as well. In the nineties, shopping online was the other kind of e-commerce that was introduced in the business (Wikipedia). Anyone who has been into shopping online will not miss e-bay. E-bay is one shopping center online that has recently been a favorite of those who loves to do shopping without a hassle. E-bay has been in the business for twelve years. This company has been a fruit of a trial and error of three prominent people in the business now. The three icons of e-bay are Pierre Omidyar, Meg Whitman and Jim Griffith. These three have made a beautiful outcome of a trial business that has been a very good decision. If to be compared to its contemporary e-commerce websites that were born the same time that they were, their capitalization is twenty five percent more than that of its counterpart (Maney, 2005). What is the secret behind e-bay’s success? What is the organizational framework of e-bay that aid them in generating more than they have imagined in a business that some has notes as skeptical? What could be the organizational strategies of e-bay? Literature Review Anyone who gets into business has only one thing in mind, success. Success for one business depends on a lot of factors. Apart from its product, the management and the team behind it matters most. This holds true especially for the e-commerce business because this needs a lot of effort on the part of the management to make it appealing to online customers and to make it worthy of trust of many to believe and give their credit card numbers and trust it with money matters. Companies try to always to check their management system is helping flourish their business. Business strategies are needed to make sure that one stays in the market long. To make sure that everything is in order, one needs to check if its employees are able to meet up the standards set by the company. The development of the use of corporate code of conducts to govern the behavior of employees has flourished since the passage of the Foreign Corrupt Practices Act (FCPA) in 1977. Back then this code of conducts or corporate social responsibility (CSR) was seen as explicit directives for the employees but today employers were able to understand that these are helpful tools in handling their employees and making their work advantageous for the company. Culture set the business behavior that surrounds a corporations code of conduct. Factors that are included are the way we comprehend the environment, how we use time and power, how we perceive space and structures. Also included is our perception of collective and individual task or relationships. If manage properly, CSR can help in fulfilling economic, social and environmental ambitions. Vital part of corporate governance will include the way codes of conduct are integrated in their operations. To make sure that a global company is competing ethically and effectively, one needs to make sure that the company’s code of conduct are made known to their employees so that they could incorporate it in their way of working (Wozniak, 1997). HSBC is one organization that provides banking and financial services that is doing its best to make up for all the losses and is giving a promising return to its consumers. They might not be the largest company but they have been awarded a couple of excellence award because of their great customer relation and promising return of investments. HSBC has now what a strategic plan they named Managing for Growth. HSBC has lay down their ways for achieving their objective of having an accelerated their rate of revenue. They still have to develop their brand strategy and improve their productivity at the same time maintaining strong position regarding management risk and financial aspect. Employees are also part of those that needs enhancing to make sure that they will be successful in achieving their goals. Part of the company’s plan is giving good rewards to those employees who will achieve the criteria that they have set (HSBC fact sheet, 2006). Every company has their own strategy but the burden lies in properly executing this strategies. Chapman (2004) has concluded that almost ninety percent of companies fail in properly executing their strategies. Studies show that when CEO’s who have failed have been interviewed said that the thing that led them to downfall was the bad execution of strategies that they have formulated. Only fourteen percent of those included in Times 1000 companies have commented that they are implementing good strategies. (Chapman, 2004) Proper management of business and financial risk is needed in order to ensure that an industry like the online shopping and any traditional company associated with it is here to stay. It is easy to acquire a debt but maintaining its positive impact in one company needs a lot of effort and planning. Business risk should be managed well and risk should be realigned in a way to cut costs; Optimized firm’s operating and financing costs; Trade off fixed charge and variable charge costs; Risk management; and when to increase and decrease risk. (Brackers, 2004) Methodology Analysis of the organizational strategies of e-bay by doing a content analysis of the documents released regarding their system of management. Findings / Results E-bay is a phenomenal hit when it comes to online shopping. Their organizational structure is just the same with other big companies. Reports shows that executives of this big company has still the traditional job titles but with a little modification with their job descriptions. To make an organizational structure of an online shopping business advantageous one needs to put more emphasis on its account management and customer relationship manpower (Keen and Qureshiï€ ª, 2006). Most of e-bays top ranking officials are graduates of good international universities and they have satisfactory working experiences as well. Most of them have taken a degree from Stanford University. E-bay has not only conquered North America but also Asia and Europe. There were twelve countries included in the Asian region, thirteen in the European region, greater part of Canada and United States (http://pages.ebay.com/aboutebay/thecompany/companyoverview.html). eBay offers more than just a place for auction; they have numerous programs that cater to the need of its client. These services include The eBay Marketplace, this is where customers could buy and sell their products; PayPal, aids in online monetary transactions of companies and individuals; Skype, is the program of e-bay that is focus on internet communication; Shopping.com, as name implies this is a site for shopping and more shopping that is; Rent.com, is the online apartment listing of eBay in the United States; and Online Classifieds, is a part of the eBay program that is an aid on the communication on a local level. (http://pages.ebay.com/aboutebay/thecompany/companyoverview.html). As recorded, the total number of eBay users worldwide has reach one hundred eighty one million. This total number of users has given eBay total revenue of $44.3 billion in 2005. The good quality of the developer of eBay is that they never loose hope despite all the adversities that they had. They wee also well in choosing in whom to put in specific spots that they needed. Pierre Omidyar, the chairman of eBay, has made a good choice when he chose Meg Whitman to handle his company. Advertisements play a major role in the success of one company as they help in creating public awareness. The first PR Manager of eBay has shown her passion for her work by creating a very good â€Å"myth† about the company. She has used every advertisement techniques to make a good reputation for the company. This good reputation of the company has been a collaboration of good advertisement techniques and good feedback of the services that they provide (Maney, 2005). Customer relationship is an important aspect in retaining customers; this could be achieved by providing a fast and reliable service. Omidyar has commented that aside from carefully managing their employees, the success of e-bay could be attributed to the right decision prowess of its CEO, Whitman. She was able to understand well that an online auction web also needs guiding and understanding the growing community of eBay sellers. Whitman’s strategy in managing the organization was being flexible and keeping in phase with the fast movement of the business (Maney, 2005). The total crash of the eBay sites that happened last June 10, 1999 has humbled the company and has teach the company on some pints regarding taking care of their system and clients as well. The system has crashed for a total of twenty-two hours. They had contacted all those affected by the system crash and this has made a direct impact on the customers, making them feel like they were really an important element of the organization. eBay has let the customers help themselves by providing a framework of a self-serve site. eBay has been an icon in the online business that even school try to use the site to teach students about e-commerce (Johnston, 2002). Conclusions/ Recommendations Any business needs an amount of risk and determination to succeed. The capital is one important factor that determines the future of one industry that is why it is important that the amount invested in any given company or business is carefully monitored if it is being use to the fullest and if it will augment to all the needs needed to make it. The capital of one company could be handled well if they have the right organizational strategies. In electronic business the common problems that may arise will be rejection of service attacks, viruses, obliteration, and theft of their intellectual property. These problems could be prevented if the organization has good managerial considerations and technical options. There should be a balance between internal and external security management (Greiger and Wegman., 2002). Each component contributes to the behavior of the system. No component has an independent effect on the system. The behavior of the system is changed if any component is removed or changed. The system has an outside an environment which provides inputs into the system and receives outputs from the system. All customers want a company that would work to their advantage without any surprises regarding deals made between him and the financial company. They would love someone who could provide them and first-rate service and a bank that has security that they could provide service for a long time. Money matter is one issue among the working citizens that requires them to think a hundred times before getting the service of any financial company. There are a lot of companies that tries to persuade them to invest in their company and that they will be getting their money’s value. Assessing one program’s effectiveness is crucial to its success. Evaluations of the advertisements and marketing strategy could guide the company if there adjustments are needed. Evaluation of the trend of existing customers would be one way of checking if objectives are being met. This could be on the form of surveys and questionnaires regarding how they foresee the services being provided. The key to a successful partnership is inter-dependency. In choosing an e-commerce site that would provide the services needed by one person, they must make sure that they are dealing with the best in the field. A customer must make sure that they are entrusting their money with the correct organization, whenever it is the traditional way or online. Reference Brackers, Kevin. (2004). Chapter 13: Capital Restructure. Pittsburg State University. Retrieved September 18, 2006 from http://www.pittstate.edu/econ/ch12326.html Chapman, Alan. (2004). Strategy Implementation and Realization. Farsight Leadership Ltd. Businessball.com. Retrieved September 18, 2006 from http://www.businessballs.com/businessstrategyimplementation.htm Greiger, Joseph and Jerry Wegman. (2002). Small Business and E-Commerce: Strategic and Legal Concerns. University of Idaho. Retrieved September 17, 2006 from http://www.cbe.uidaho.edu/wegman/geiger-wegman%202002%20website.htm HSBC fact sheet. 2006. HSBC Global Site. Retrieved September 17, 2006 from http://www.hsbc.com/hsbc/investor_centre/fast-facts Johnston, Timothy C. (2002). Using E-bay to teach E-commerce. The University of Tennessee at Martin. Retrieved September 18, 2006 from http://www.utm.edu/staff/johnston/papers/ebayteachec.doc Keen, Peter and Sajda Qureshiï€ ª. (2006). Organizational Transformation through Business Models: A Framework for Business Model Design. Proceedings of the 39th Hawaii International Conference on System Sciences. Retrieved September 18, 2006 from http://www.hicss.hawaii.edu/HICSS39/Best%20Papers/OS/08-14 05.pdf#search=organizational%20framework%20of%20ebay Maney, Kevin. (2005). 10 years ago, eBay changed the world. USA Today. Retrieved September 18, 2006 from http://www.usatoday.com/tech/news/2005-03-21-ebay-cover_x.htm Miner, John B. (2005) Organizational Behavior I: Essential Theories of Motivation and Leadership. HF5549 2005-003746 0-7656-1523-1 Sharpe, Inc. Reference Research Book News. Retrieved September 18, 2006 from http://www.findarticles.com/p/search?tb=artqt=Organizational+behavior+/+Analysis Sharpened Productions. (2006). Definition of E-commerce. Retrieved September 18, 2006 from http://www.sharpened.net/glossary/definition.php?ecommerce The Ebay company. Retrieved September 18, 2006 from http://pages.ebay.com/aboutebay/thecompany/companyoverview.html Wikipedia. (2006) E-commerce. Retrieved September 17, 2006 from http://en.wikipedia.org/wiki/Electronic_commerce Wozniak, Lynne. (1997) International Business Ethics: When a Corporate Code of Conduct is Not Enough.. Relocation Journal Real Estate News. Retrieved September 17, 2006 from http://www.relojournal.com/july97/ethics.htm

Bill Gates :: essays research papers

In his high school years, Bill Gates proclaimed that one day he would be a millionaire. He greatly underestimated himself. He became interested in computers while in the 8th grade. His school received a hookup to a high powered computer. Bill and his good friend Paul Allen used to skip gym class to use the computer. Sometimes they would even break into the school at night to spend time on the computer. Eventually Bill made his first program. A virtual tic-tac-toe game. The Computer Center Corporation (CCC) wanted to rent a computer from the Digital Co., but they couldn't pay for it. Digital said they would provide it at no cost if they could find any bugs in their computer. CCC put an add out in the local paper, and Bill and Paul applied immediately. Although skeptical about hiring two teenagers to do the job, their doubts were quickly dissolved. When they were done, Bill and Paul had compiled a list of bugs that was over 300 pages long! Bill was next hired by his school. They wanted him to write a program for use in class scheduling. Bill was happy to do it. He used a programming language called FORTRAN for the first time in this program. FORTRAN was one of the major languages later used at Microsoft. With this program, Bill first took advantage of his skills. He designed the program to put him in classes with no other boys and all the girls he thought were cute, what a guy! At this time Paul and Bill also started their first company called Traf-O-Data. Keep in mind that they are still in high school! They designed a program that could analyze traffic counts by machine so counties could get government funding for road projects. They had clients in British Colombia and Delaware but went out of business in 1973 when the government offered the same services for no charge. Bill Gates scored a perfect 800 on the math portion of the SAT's. However, instead of going into computers, which would seem logical, he went to Harvard to become a lawyer. In 1974, a company in Albuquerque, NM, known as MITS made the first home computer. The computer was useless because it had no monitor or keyboard. In place, it had switches to input data and a device similar to a printer to display data. This computer was called Altair and when Bill and Paul heard about it, they were a-twitter.

Personal Finance Essay

Without financial knowledge, a budget and/or a financial plan in place you can have an income of 100,000 thousand dollars a year and still be living paycheck to paycheck and eventually end up in financial ruin. If a budget is not in place it is very likely to spend more money than you are making. By accounting for all income you receive and spend you are able see you’re spending habits. To assess whether you’re spending habits are good or bad, need to be improved or adjusted. For instance my family loves to eat out. If I noticed that my family spends $400 dollars a month on fast food/eating out then I need to decide what’s essential to my household and what’s not; if spending that amount on fast food is not essential then I need to make a conscience effort to eat at home more and decide on an acceptable amount and give my family a fast food budget, a certain amount for fast food monthly. I can also add that additional money not spent on eating out to our savings account or add it to a 401k, IRA, or even pay extra on our credit cards. By making good personal finance choices money can be saved monthly to add to retirement income. Personal finance choices affect your life now but most importantly they will affect how comfortable you are able to retire. To design a budget for earnings, spending, saving and investing a financial plan is a necessity. To create a financial plan for earnings, spending, saving and investing you must first understand these things separately, how they all work together and affect each other and that they are a necessity to laying a solid foundation for your family’s future. First, a detailed budget is needed for a clear picture to see how much money you have, what you spend your money on, how much you’re spending and the amount left over. A budget allows you to make sure your money is going where it should. After a budget is created and you’ve cut back on the little things that aren’t essential and you’ve focused on getting out of debt by not borrowing more than you can afford to pay back and paying more than just the minimum on credit payments then it’s time to focus on a plan for saving and investing. It is important to take advantage of tax – advantaged accounts like employer 401k plans, individual retirement accounts and special retirement accounts for the self employed. These accounts give way for credits, tax deductions and tax free earning on retirement savings. Insurance is also an important part of this process to protect your life, your capability to earn income and the roof over your head.

Od Interventions

Definition of od interventions: An OD intervention can be defined as â€Å"the set of structured activities in which selected organization units engage with a task or a sequence of tasks where the task goals are related directly or indirectly to organizational improvement † â€Å"A set of sequenced and planned actions or events intended to help the organisation increase its effectiveness†. In an od intervention the entire process of diagnosis, alternative generation and making action choices are jointly conducted and od will also examine the process of such diagnosis, action planning and implementation.Criteria for Effective Interventions: In OD three major criteria define the effectiveness of an intervention: 1. The Extent to Which it (the Intervention) fits the needs of the organization. 2. The degree to which it is based on causal knowledge of intended outcomes 3. The extent to which the OD intervention transfers change-management competence to organization members. Characteristics of od intervention: First An od intervention will focus on the organizational processes apart from the substantive content of an activity.Secondly an od intervention would generally focus on a work team as the unit of analysis and change towards effective behaviour Thirdly od would normally view change as an on-going process and would rely on a collaborative management of work culture Types of od interventions : These interventions can be clubbed into twelve groups and they are diagnostic, team-building, inter-group activities, survey feedback methods, education and training programmes, techno-structural activities, process consultation, the management grid, meditation and negotiation activities, coaching and counseling and planning and goal setting activities. ) Survey Feedback: It recounts to an approach survey through well planned assessment or Interviews. It covers the feedback to the customer organisation. It has a demand and significance in a genuine situation. The attitude survey can have a purpose to measure the process; for instance, communication, decision making and leadership at different levels. The data produced under this system is perceptual and attitudinal.. A review of the product is prepared in a group discussion.Generally feedback of results is specific to the group which prepares the data. As a result strategies are planned to resolve the organisational problems. Consequently, the process of survey feed back includes: collection of data, feedback, development of action plan and follow-up. Therefore, to ensure authentic results, the survey should be applicable and dependable. 2) Management Grid : The method urbanized by Robert Blake and Jane S. Mouton is a step to move toward. This Grid represents a rational support of managing people.Growth of management skills from beginning to end grid program involves wide range of included and instrumented activities are the ways having investigational and planned conditions. The member s are secondary to be pleased about the advances to integrate people and their invention. 3) Team Building: Team building is an attempt to assist the work group to identify, diagnose and solve its own problems. Actually groups develop their own norms of behaviour which pressurize the persons and group behaviour. Organisation is a system to interconnect with groups.OD considers that work groups are the teams which are spinning around to introduce changes in the organization. Team building actions are taken to develop a range of groups in an organization like permanent work teams, task forces, committees etc. Team building actions focus on finding, task achievement, team relationships and organisational process. The component groups in team building activity are: the external advisors, the group leader and the members of the group. In team building movement, associates meet and talk about troubles connecting to their coursework It obtain sincere and courageous argument.In the team bui lding movements, the associate adds the sequence relating to their personal observation of issues, problems and task relationship. 4) Sensitivity Training: It is known as training being carried out by creating an experimental laboratory circumstances where workers will be brought together to do something together in a formless environment. Sensitivity training helps in understanding people well again, to develop appreciation for others, to develop specific behavioral skills and to gain effective approach into the group development. It also aims at falling interpersonal confrontation.The main aim of sensitivity training is to split all the methods through the bond of silence and ease the expression of associates to emphasize on the process of debate to a certain extent than to fulfill the instructions. It is a method which proposes to have brain washing of persons. This training is accepted by formless groups without any agenda, leader and predetermined goals. The group is given inde pendence to expand their plans, contacts and on going process for interaction. Sensitivity training gives a technique to enable special knowledge and development. ) Four System Management : Rensis Likert’s four System Management has given four stage to represent the organizational values to include the essential collection of job bearing and people way. According to Likert management philosophy can be classified into four systems they are: i) Exploitative-Autocratic System ii) Benevolent Autocratic System iii) Consultative Democratic System and iv) Participative Democratic System. This theory explains that three basic concepts of system has four management which will help making the organization effective they are: ) To use the principle of supportive relationship in the organisation b) To use the group decision making and group methods of supervision in the organisation, and c) To emphasize more on the high performance goals. 6) Management by Objectives (MBO): It is another important tool of O. D and involves the process of educating the concerned persons about M. B. O, agreement upon clear cut quantifiable objectives, evaluation of objectives and feedback for deviation and coercive action. . M. B. O is wide-ranging overall managerial philosophies that focuses upon joint goal setting and synthesize the individual’s goal to organisational goals.The entire organization will have the feeling of unity as all levels of management of an organization are involved in goal setting. The programmes relating to M. B. O can be effective if they are properly implemented and needs the support of the top management. 7) Process Consultation: It can be described as the set of activities on the part of the consultant that helps the client to perceive, understand and act upon the process events that take place in the client’s environment. Process consultation concentrates on the analysis of process of activities like communication, leadership etc.It also aim s to attempts to develop initial contacts, define relationships, selecting the method of work, collection of data and diagnosis. Process consultation is a method of intervening in an on going system and is designed to change attitudes, values, interpersonal skills, group norms, and cohesiveness and other process variables. 8) Contingency Approach : This approach was given by P. Lawsence and J. Lorseh. It is based on the principle that an organisation is a multifaceted social system. Its behavior must be included into a united effort to enable it to cope with the environment.Theoretically individuals in different departments have different orientations related to the tasks they perform. Genuinely, the organisational units in their regular operations they are differentiated along with their direction. It appears that with the task discrimination coordination is not possible. According to contingency approach separation and combination are possible for total organisation’s effec tiveness with the help of integrative devices. To sum up, high organisational presentation is well-suited with the existence of both separation as well as combination which are required as per the stress of heir immediate environment. The contingency approach can be useful as an OD intervention in industrial organizations in the form of inter group argument meetings of concerned departmental persons. 9) Role Analysis : In the presentation of their individual roles persons manifest certain behaviour which may upset team efficiency. At times it is established that the persons are unambiguous about their own expected behaviour from the view point of other members of the team. In these circumstances the role analysis procedure is used to clarify the role expectations and obligations of the members of a team.The ensuing role requirements and the expected behavioral mechanism of each other help the member enjoy an equally acceptable behaviour in the team work. In this technique, the indiv idual role players analyze the focal role of the individuals. 10) Inter-group Activity : Meager interpersonal relations are not unusual features in organisational performance . Under these circumstances, inter-group motion spotlights to improve the relationships between the groups. It helps in the interaction and communication between the work groups which eventually avoids dysfunctional inimical competitiveness among them.Inter-group team building entails the procedure of discrimination and combination. 11) Organisation Mirroring: It monitors the activities of group of members and gets the feedback from the members of several other groups about how is it being professed. Organisational mirroring is used when there is complexity with other department in the organisation. A meeting is called and response is sought from other department. During the meeting the correct picture emerges which will determine many mistakes committed between two groups. 2) Third Party Peace Making Intervent ion: This intervention is the foundation of the thoughts to understand the conflicts and their resolutions at the interpersonal level. It helps to confront the method of resolving the conflicts takes place between two parties who are aware of the existence of the conflicts and want to confront the issues. The advisor as a third party must be accomplished in the art of identifies the conflicts and use confrontation as technique. This process focuses on four basic elements of conflicts they are : i) The conflict issues, (ii) The contributory circumstances, (iii) The conflict related behaviour, and (iv) The results of the conflict. 13) Job Design/Redesign : It is task -technology connected approach and aims at making changes in the work procedure of the groups of employees. Job design occupies a well planned reorganization of a job. On the whole it focuses to develop worker’s motivation, commitment, performance, job satisfaction etc. , through job enrichment, job engineering, jo b rotation, job enlargement and socio-technical system. 4) Quality Circles: Quality Circles are semi-autonomous work groups with six persons who volunteer to talk about and solve feature related problems during working hours. It has impact on working conditions, employee’s commitment and self development of employees. 15) Counselling : Counselling is the method to extend the help by a manager to his assistant to enhance his prospective. It plans at hypothesizing and empathize with the workers. It assists to bring about self consciousness in the worker about his capability. Single or group of interventions may be used to resolve the issues.Od intervention used in BHEL-BLOCK5 PAGE33-34(M) In order to develop & improve the effectiveness of the human resources in the Organisation, a committee called ‘Human Resources Committee’ was first constituted by BHEL in Bhopal in 1976. The committee is the central body and plays the central role in implementation of all OD effo rts. With the help of external and internal resource persons, a number of programmes/workshops have been Organised for the development of the members of this committee improving their problem solving capabilities and decision making.The range of OD interventions are described below. Job Redesign and Work commitment as an OD intervention In one of the BHEL units (Hardwar) Job redesign was taken up and as an OD intervention in 1975. This experiment was pursued for around 4 years and very encouraging results were obtained. i) A more satisfying job, due to increased variety and relief from boredom and monotony ii) Personal growth for all, by learning additional skills of other trends and acquiring leadership Qualities iii) Reduction in health/safety hazards iv) An atmosphere with less tension and jealousy ) An improved team spirit and morale resulting in improved communication and human relationship vi) Increased self esteem and pride among the workers. Workshops were conducted and it w as found to be very useful and threw up more questions for wider debate and discussions. By using survey method, a list of programmes or subjects or themes is sent to various. H. O. Ds who respond by ticking the appropriate ones for their executives. As a result of various diagnostic exercises some critical needs of training and development are identified.The workshops on various themes also give valuable idea of the areas requiring more thrust by way of training and development and specific training and development needs are thus identified. Based on role analysis a draft system with the following objectives has been circulated by the Corporate Personnel for the comments of Personnel/Training (HRD)/Divisional Heads. . Helping the executives to become more effective in their present and future jobs. . Enabling the executives to perform at optimum level by determining and meeting their growth needs. . Helping the executives to visualise their roles more clearly. Preventing the obsole scence of their technical and managerial skills. . Optimising the utilization of training resources by providing appropriate inputs. . Facilitating the design of need based programmes and identify the training and development needs. . Preparing data bank of capabilities required for various positions. . Facilitating job rotation, career and succession planning. Once implemented, it will provide a valuable data base for planning, training and development activities and identifying appropriate candidates for programmes. Performance Appraisal and Potenfial AppraisalIn BHEL it has remained so far that the role of superior was limited to evaluator or judge and the role of the appraisee was passive. Now the superiors role is being conceived as helper and counseller and the appraisee is encouraged to become more involved and committed in achieving the objectives. Performance feedback and Counselling The need and importance of performance feedback and counseling has been realized. Attempts are being made to cover maximum number of executives in various programme/workshops on performance feedback and counselling to enable them to practice it as an important tool for Human Resource Development.The supervisors also will be covered in such efforts. Career Planning and Development Time-cum-merit based promotion was practiced which is able to satisfy the individuals and organizational needs to a great extent. The employees are encouraged and helped to plan a career path. They are liberally sponsored to higher educational programmes in IIMS/IITs. Posted bySatish Raj Pathakat9:19 PM Labels:OD intervention Od intervention at NTPC

Applications Of Solar Energy Draft Essay

Applications Of Solar Energy Draft Essay Applications Of Solar Energy Draft Essay Introduction: Applications of Solar Energy Solar Energy is the wave of the future. Its use has increased tremendously over the last decade. It is used in many different places and seems to be replacing the traditional methods of obtaining energy at an astounding rate. It’s really no wonder why we would embrace the concept of Solar Energy. There are various ways this energy is used and even more way in which it has benefited today’s society. Solar energy stands alone in its own class of sun powered energy. However, there are many diverse way as to how it can be used. Solar energy is the cleanest power generating systems today. It is not harsh on our environment making it a safe and wise choice. There is no pollution, noise, or hazardous waste as a result of this conversion of the sun’s energy. The electricity created is clean, reliable, and renewable. The use of Solar Energy also decreases our dependence on fossil fuel and other energy sources much less friendly on our environment by reducing greenhouse gases. Solar power systems are cost efficient and provide it’s users with fixed energy costs. As the use for this â€Å"clean energy† increases so does the development opportunities and local jobs. The use of heat and light simultaneously obtained from the sun is a brilliant and beneficial asset to us on many different levels. Solar energy has propelled our economy and has driven us further into the future. It’s no wonder why we are relying more and more on this type of energy. How we use Solar Energy In order to utilize the sun’s energy, there must be some type of conversion for channeling. This device is called Photovoltaic (PV devices). It can also be referred to as â€Å"solar cells† which transform sunlight into direct electricity. These PV cells are individually grouped into sections which are used in a vast array of applications sometimes ranging from small single cells that are capable of charging small watches, to larger, more complex systems that are capable of powering homes and even expanding to power plants that may cover many acres of land. Photovoltaic is a method used to generate electricity through solar radiation while transforming direct electricity by using semiconductors which display photovoltaic effect. This power generation uses solar powered panels consisting of numerous solar cells of photovoltaic material. There are several materials used to make photovoltaics including copper indium gallium, polycrystalline silicon, cadmium telluride, m onocrystalline silicon, and selenide/sulfide. As the demand for renewable energy increases, the development of photovoltaic systems and solar cells made astounding advancement over the past few years. Photovoltaic systems or PV’s rely on solar panels in order to change light from the sun into usable electricity. â€Å"This system is made up of one or more photovoltaic (PV) panels, a DC/AC power converter (also known as an inverter), a racking system that holds the solar panels, electrical interconnections, and mounting for other components. Optionally it may include a maximum power point tracker (MPPT), battery system and charger, solar tracker, energy management software, solar concentrators or other equipment†. A compact PV system would provide enough energy for one consumer, or even to an isolated device similar to a small weather instrument of lamp. Larger PV systems connected on a grid can provide enough energy for a large number of consumers. This electricity can be used directly, stored, combined with other generators fed through a small grid (called a hybrid plant), can be either stored, used directly (island/standalone plant), or fed into a large electricity grid powered by central plants. These systems are specifically designed to guarantee that the best (highest) energy yield for a given investment in obtained. Solar photovoltaics are one type of sustainable energy source used to convert sunlight into electricity. â€Å"By the end of 2011, a total of 67.4 GW had

Asian American Literature Essay Research Paper It

Asiatic American Literature Essay, Research PaperIt is true that all people are created different, and therefore no two civilizations will of all time be the same. Throughout Asiatic American literature at that place seems to be a battle between the Asiatic civilization and American civilization. More specifically, there is a battle between Asiatic adult females and their Asiatic American girls, and what it means to be feminine, and how a adult female should move. The chief battle is between how the American adult female should move and how the Asiatic adult female should move. However, the behaviour of the Asian adult female seems to be dominant through out the narrative because although the girls and the female parents may non acquire along all of the clip, the female parents to have a batch of regard from their girls. Therefore, the female parents sentiment on how they should move, which is acting like the Asian adult female, is most apparent. This is the instance in The Joy Luck Club, written by Amy Tan and besides in the short narrative # 8220 ; Waiting for Mr. Kim, # 8221 ; written by Carol Roh-Spaulding. These two narratives have really different significances, nevertheless they are similar in the facet that they are all Asiatic adult females with Asiatic American girls seeking to acquire their girls to maintain and utilize their Asiatic heritage. There are certain behaviours that Asiatic adult females are expected to hold, and the female parents feel that their girls should utilize these behaviours. In The Joy Luck Club, the novel traces the destiny of the four mothers-Suyuan Woo, An-mei Hsu, Lindo Jong, and Ying-ying St. Clair-and their four daughters-June Woo, Rose Hsu Jordan, Waverly Jong, and Lena St. Clair. Through the experiences that these characters go through, they become adult females. The female parents all fled China in the 1940 # 8217 ; s and they all retain much of their heritage. Their heritage focuses on what is means to be a female, but more significantly what it means to be an Asiatic female. In the short narrative # 8220 ; Waiting for Mr. Kim, # 8221 ; the chief female character Gracie understands what it means to be an Asiatic female, but she does oppugn the significance because of her sisters. Her sisters ran off from place before their matrimony could be arranged and eloped. This is wholly against Asiatic civilization, and it causes Gracie to oppugn her heritage and her Asiatic muliebrity. In both of these narratives there are certain features of females that are the same, they are interior strength, obeisance, award and regard, the good of the whole is better than the good of the person, and happening things out for yourself. In the chapter # 8220 ; Scar # 8221 ; the feature of award and regard is foremost noticed. In this chapter An-mei finds out how her female parent fundamentally deserted her, her female parent did go forth for a good ground, which was to keep the award of her household, but either manner her female parent left her. Her grandma had to raise her, and she learned much about the Asiatic adult female from her. An-mei was demoing some disrespect towards on of her aunts, and her aunt told her that she was being disrespectful. Her grandma so interjected and said, # 8220 ; When you lose your face, An-mei? it is like dropping your necklace down a well. The lone manner you can acquire it back is to fall in after it. # 8221 ; She was speaking about A-mei # 8217 ; s female parent, and how she left because she had disrespected the household and she was dishonourable to the household name. The lone manner for her female parent to recover regard and award was to go forth and make it on her ain, which is a feature of an Asiatic adult female. Another feminine feature that comes from that scene is being able to make things on your ain. However, this is an American influence. This characteristic comes from the chapter # 8220 ; Rules of the Game. # 8221 ; This is a curious chapter in the book because it is a chapter where the adult female is non seen as inferior to the adult male. Waverly # 8217 ; s brother, Vincent, received a cheat set for Christmas. However, Waverly is the 1 who took full usage of the cheat set. She was a natural, she would crush her brothers in cheat, which would usually be looked down upon in Asiatic civilization, but she was encouraged. She was even given lessons in cheat, and she was a national title-holder. Unlike An-mei # 8217 ; s female parent, Waverly was conveying award to the household name. When Waverly is encouraged to stand out in cheat she learns something from her female parent. Her female parent said in her broken English, # 8220 ; This American regulations? Every clip people come out from a foreign state, must cognize regulations. You non cognize, justice say, Too bad, travel back. They non stating you why so you can utilize their manner to travel frontward. They say, Don # 8217 ; Ts know why, you find out your self. # 8221 ; This is an American usage, more than an Asiatic 1. She is explicating that in order to win as an Asiatic female in the United States, so there are certain things that you will hold to happen out on your ain. Besides in this chapter was the theme/characteristic of inner streng th. Waverly says she six when her mother taught her the â€Å"art of invisible strength.† Waverly was walking by the candy store when she was a young child, and she was begging her mother to take her inside. Her mother refused to take her inside, which angered Waverly. Then her mother went on to explain, â€Å"Wise guy, he not go against wind. In Chinese we say, Come from South blow with wind-poom!-North will follow. Strongest wind cannot be seen.† This means that the strongest way to win an argument is to keep to yourself, which Waverly used in her chess matches. Waverly goes on to say, â€Å"A little knowledge withheld is a great advantage one should store for future use.† Another example of invisible strength, inner strength, is the â€Å"The Moon Lady.† Ying-ying’s mother was telling her how a woman should act when she said, â€Å"A boy can run and chase dragonflies?But a girl should stand still.† The girl would have a better chance cat ching the dragonfly than the boy, she would catch the dragonfly with inner strength, rather than muscle like the boy. The chapter, â€Å"The Moon Lady,† has another characteristic of what it is to be female, which is the good of the whole is more important than the good of the individual. They were all on their way to see the Moon Lady, and if you see the Moon Lady, you receive one wish from her. Ying-ying asked what a â€Å"secret wish† was, and the answer was that is was on that you cannot ask. Ying-ying was young as this point, so she asked why. Amah’s response to Ying-ying was, â€Å"This is because?because if you ask it?it is no longer a wish but a selfish desire?Haven’t I taught you-that it is wrong to think of our own needs? A girl can never ask, only listen.† Here she is telling that by making a wish for herself she is being selfish and forgetting that she is not the important one, but the good of the whole is the important one. Amah is als o hinting at obedience when she tells her daughter that she is not to ask questions, but just listen to the men and go along with it. Arranged marriages are a very tough thing to go through. Marrying someone because one has to has to be hard because one is not marrying out of love. This is exactly the case in â€Å"Waiting for Mr. Kim.† Gracie two twin sisters have already run away from to and eloped with two men. Their marriages were not arranged because they left before their father could arrange them. Now, with her sisters gone, Gracie is the only remaining daughter, and she is somewhat frowned upon because she was the â€Å"third daughter.† She did not really like the two men that her father was thinking of arranging the marriage with, but it did not matter. It did not matter because as her mother told her, â€Å"Girls don’t choose.† The girls just sit there and look pretty while their fathers choose for them, they have to comply with their fatherâ₠¬â„¢s decision. They are obedient, and at the same time respectful of the decision that is made. Another characteristic that appears in this story is that women made to think that they are second class compared to men. When her Mr. Kang, Gracie’s father, would walk, he would sometimes reach back to hold Mrs. Kang’s hand, but she would pull away. Not only would she pull away, but she would â€Å"stay behind as she cleaned her purse or took forever with her coat, just to have it the way she had learned it, her husband a few places ahead, women behind.† Her mother not only believes that this is how women should act and it is a part of their femininity, but she is passing this way of thinking onto her daughter. Her mother is relaying the message to her daughter that no matter what you need to show your husband respect and let him know that he is in charge. Both of these stories have displayed that there are certain characteristics of females and they are inner stren gth, the good of the whole is better than the good of the individual, find things out for oneself, honor and respect, and obedience. All of these characteristics have displayed not only what it means to be feminine, but also what it means to be female. It is not so much an Asian female, but it is because that is how their mothers were raised and that is how their mothers will raise them. There are really no American females for the daughters, or mothers, to see and mimic. The only way of life that the mothers know is the Asian way of life, therefore that is the only way that can be passed down onto their daughters. Sometimes that is hard for the daughters to understand because the daughters have grown up in American culture, and they know what it is like to be an American woman. No matter how one views this situation, these stories focus on what it means to an Asian female, but more generally what the mothers know best on how to teach their daughters on how to be female.

Managing Conflict and Negotiating Essay Example | Topics and Well Written Essays - 500 words

Managing Conflict and Negotiating - Essay Example for instance can easily be managed or hindered even though everyone is competing is the thought that the human resource is appreciated as all best in their own way and are capable of innovating the best possible products. An organization is susceptible to fail because of lack of teamwork. In order to apply the idea of affiliation in an organization, teamwork must prevail and should be added as substantial core value, in order to help everyone treat each other as colleagues rather than adversaries. One way to improve cohesiveness of a team is to employ this idea, which tries to influence everyone to work as one for the same goal. Another important core value that should be initiated along the process of conflict management is respect. An organization is susceptible to incur troubles due to lose of respect. In the presence of respect, autonomy could be exercised. A team requires everyone to have respect for each other especially in the kind of decision they make. To ensure conflict will be managed, each department for instance, must be able to be allowed to exercise their freedom to decide for as long as everything is fully in line with the company’s direction. At small scale, the same approach must be initiated among everybody in the group. Another core value that could be enhanced in an organization is recognition, which could promote individual status. Superiority complex is common to every organization. Nobody should be treated inferior as there must be something in each of one that could be recognized as potential contribution to the entire team. In this case, it would be important to initiate quarterly evaluation of individual performance and commending with all sincerity where each one might be good at, by which the point of doing this is to minimize superiority complex within the team. Mostly, conflicts ignite from existing role. The accounting department and marketing department for instance usually have conflicting roles. For this reason, it is

Unit 6 Seminar Public Health Essay Example | Topics and Well Written Essays - 250 words

Unit 6 Seminar Public Health - Essay Example In addition, barrier protections have been a routine part of all health care institutions in reducing the spread of disease. Riegelman (2010) define immunization as the introduction of antibodies/vaccine to strengthen the immune system and to prevent or control diseases (102). Immunizations are essential to the protection of the public because it prevent infection from bacterial and viral diseases, provide either short/long-term immunity, may effectively control outbreak, and can control 70-90% of substantial population with infections from contagious viruses. On the other hand, a number of disadvantages were also noted, among of which are: some diseases such as HIV/AIDS may not have effective vaccines, immunizations are rarely 100% effective particularly among the young and the old and can produce side effects such as allergic reactions, live vaccines may cause injury to fetus or diseases to those with reduced immunity, and immunizations through inactivated vaccine may not produce long-term immunity and thus requires follow-up vaccines/boosters. Barrier protections also include isolation and quarantine. Isolation refers to the separation of the individuals with diseases from healthy population in order to prevent exposure (Riegelman, 2010, 102). Isolation and quarantine have the advantage of controlling the spread of a number of infections and serve as the basic strategies for controlling communicable diseases such as HIV/AIDS, chlamydia, gonorrhea, and syphilis. However, isolation and quarantine may possibly break confidentiality of contacts’ information due to identification of individuals with diseases and follow-up of contacts. It may also lead to public recognition and social stigma placed upon affected individuals. Barrier protections such as immunizations, isolation, and quarantine encompass treatment of those with disease and their contacts and are all essential comprehensive

US covert action Essay Example | Topics and Well Written Essays - 2000 words

US covert action - Essay Example programs and policies abroad that are not apparent or acknowledged publicly. Whether it is a realistic expectation for U.S. to continue with covert action? There is no realistic expectation that U.S. can continue with covert actions without been discovered. Covert action remains a third option for American foreign policy beyond the initial two options of diplomacy and combat. On covert action, the CIA can be regarded as damned when they do, and damned when they do not. Can one expect the U.S. hand to remain "hidden" even if the action is discovered? Covert actions details activities of the U.S. government to influence political, military, or economic conditions abroad. The U.S. government conceals its responsibility based on the justification that the U.S. responsibility would render an operation infeasible. The core objective of covert action rests on influencing events overseas secretly and in support of U.S. foreign policy.2 The U.S. would be overly optimistic for its hand to rema in â€Å"hidden† even if the action is discovered.... For instance, if Israel was to admit having a nuclear program, such an action can trigger a nuclear arms race within the Middle East, who may feel threatened by Israel. Plausible deniability or the non-attribution to the U.S. for its covert operations makes it impossible to trace back to their point of origin. Plausible deniability is pertinent in protecting the U.S., and it operatives’ from the consequences of disclosures. Measures to make covert action a continued viable policy? Covert action is a necessary, but controversial instrument for U.S. foreign policy. The government should undertake covert actions only if: the intentions and objectives are concisely spelled out, just, and reasonable; there is a reasonable possibility of success; the methods envisaged are commensurate with the objectives; and, due deliberation undertaken with the full knowledge and concurrence of appropriate constituents. Question 2: (A) What was the objective of each operation? The overthrow of Mos sadeq in Iran (1953) arose when Kermit Roosevelt and few other CIA operatives orchestrated a successful coup against Iranian Prime Minister Mohammad Mossadeq the U.S perceived as becoming allied with Iran’s Soviet-dominated Tudeh Party. Roosevelt secured the hesitant support of the Shah dismissing Mossadeq. Zahedi, a highly ranking officer, selected to lead the coup.5 In the wake of the success of the Iranian operation, the CIA also orchestrated a combination of both military and psychological pressures to force leftist Guatemala president, Jacobo Arbenz from office in 1954. The operation (labeled as Operation BPSUCCESS) utilized an invasion by a ragtag â€Å"liberation† army, fictional arms drops, psychologically effective CIA air attacks, and disinformation disseminated to prompt

Effect of Oxidative Stress on HAGE Expression

Effect of Oxidative Stress on HAGE Expression Cancer is a group of diseases which involves uncontrolled cell growth, metastasis and invasion of cells to other tissues via lymph node or blood. Cancer is caused by many factors such as (i) Chemicals such as tobacco, alcohol, asbestos etc., (ii) Viral infections such as Human Papiloma Virus, Epstin Barr Virus, hepatitis B, C etc., (iii) Ionizing radiations such as X-Rays, UV-Rays, Gamma Rays etc., (iv) Hereditary factors such as mutations in BRCA 1 and BRCA 2, p53 mutations, APC gene mutations, Retinoblastoma gene mutation etc., (v) Hormones which promote growth proliferation such as growth hormones, estrogen, progesterone etc. Cancer is classified into malignant and benign tumours. Malignant tumours are mostly liquid tumours which metastasize to other tissues via lymph node and blood. Benign tumours are mostly solid tumours which stay at one particular tissue and seldom migrate. Malignant and Benign tumours are re classified on the type of cell and tissue from which they originate. They are classified as follows: i) Carcinomas: These are the malignancies of the epithelial cells, which line the internal organs of the body and also present on the surface the body such as skin. ii) Sarcomas: These are solid tumours present in connective tissues such as bones and lymph systems (Crowley 2006) Furthermore the tumours are classified according to (i) site of origin as in lung cancer, breast cancer etc., (ii) type of cell such as rhabdomyosarcoma and acute lymphocytic leukaemia. (Ruddon 2007) The progression from a normal cell to malignant one involves the dysregulation of genes implicated in the control of normal proliferation / death over many years. These are normal functions regulated by proto-oncogenes and tumour suppressor genes. Proto-Oncogene And Tumour Suppressor Gene Protooncogene is found to be normally expressed in all vertebrates including humans. It is also found to be expressed in some insects and yeasts. Protooncogenes play an important role regulating normal cell growth and differentiation. They also perform functions such as signal transduction and mitogenic signal execution RAS, MYC, TRK, ERK are some examples of protooncogenes (Novakofski 1991). Oncogenes are derived from protooncogenes during the process of carcinogenesis. The formation of active oncogene leads to abnormal cell proliferation and thus contributes to the formation of tumour (Alitalo and Schwab 1986). A protooncogene can be converted into an oncogene in a variety of ways such as (i)Transduction induced by retroviruses which cause the integration viral DNA with the host. This DNA on translation give rise to viral proteins which cause the activation of protooncogene, thereby leading to cancer. (ii) Mutation within the protooncogene leading to an increased activity of the pr otein. (iii) chromosomal translocation where the gene for proto oncogene is translocated to other loci, which cause its abnormal expression. For eg in the translocation of abl in chromosome 9 to bcr region chromosome 22 as found in Philadelphia chromosome (Rowley 1973) (iv) Amplification induced by gene duplication, mis-regulation of gene which leads to overexpression of protooncogenes. (Todd and Munger 1999) Unlike oncogenes, the tumour suppressor genes normally inhibit cell growth in variety of ways such as (i) repressing the genes important for cell cycle progression. For eg., pRb (retinoblastoma ) controls the G1 stage by being hypophosphoryated and not allowing the release of transcription factor E2F which promotes G1-S transition. (ii) Stopping cell cycle on detecting DNA damage. DNA damage induces p53 which now leaves from its interacting partner Mdm2 and increases the activity of p21. This p21 protein then inactivates cyclin dependent kinases which are essential for cell cycle progression, (iii) Apoptosis may also be promoted by p53 when damage is irreversible. (iv) inducing DNA repair proteins to repair DNA damage and prevent abnormal cell proliferation. (Yoshida, et al. 2000) There are a number of mechanisms by which a cancer cell survives in a body. This is illustrated in the diagram below.(Weinberg and Hanahan, 2000) Treatment The choice of therapy depends upon the location and stage / grade of the tumour, as well as the health of the patient. There are a number of therapies for treating cancer such as surgery, chemotherapy, radiaotherapy, hormonal therapy etc., The deregulation of many genes in cancer cells leads to the over-expression of altered proteins which can be used as biomarker which can provide help for the diagnosis and / prognosis of the treatment but can also be used as potential target for immunotherapy. Cancer antigens and their classification Tumour antigen is an antigenic substance produced in the tumour cells and triggers an immune reaction in the host. They are useful in identifying tumour cells and are used in cancer therapy. Tumour antigens are classified as Cancer testis antigen, Differentiation antigens, Tumour specific unique antigens, Overexpressed Self Antigens, Viral antigens, Post-translationally, Oncofoetal antigens, Idiotypic Antigens as shown in the table below Copied from (Li, et al. 2005) Amongst all these categories, cancer testis antigen represent the most promising group of antigen to be used in future immunotherapeutic interventions due to their restricted expression to mainly to tumour cells with the exception of placenta and testis which are immune-privileged sites and therefore would not pose any real issue for the risk of autoimmunity.(Simpson, et al. 2005) HAGE HAGE also known as DDX43 and CT13 antigen belongs to this category of antigens and was first identified by Martelange et al using cDNA subtraction approach of a human sarcoma cell line.(Martelange, et al. 2000)Using rational hybrid analysis, it was found that HAGE gene is located on chromosome 6. HAGE was found to be overexpressed in several tumours. There is a low expression of HAGE in normal tissues since the expression is regulated by hypermethylation HAGE is also over expressed in tissues such as testis, placenta, and ovaries. HAGE is usually expressed at the m-RNA level though recent studies in melanoma cells suggest that HAGE could also be expressed at the protein level.(Mathieu, et al. 2010) The name DDX43 comes from the fact that HAGE also belongs to another group of protein known as Dead box proteins and referred to as DDX43. (Abdelhaleem 2004) Dead box proteins These proteins were discovered in the late 1980s. (Gorbalenya, et al. 1989)Dead box proteins belong to the family of RNA helicases and play an important role in the transcription, post transcriptional modifications such as splicing, transport, translation, decay and biogenesis of ribosomes. NTP hydrolysis provides energy to these enzymes and they unwind dsRNA or disrupt RNA-Protein interaction. DDX and DHX are widely studied Dead Box Proteins. There are many classes of DDX and HAGE belongs to DDX43. They are so named because they contain the amino acids D-E-A-D (Asp-Glu-Ala-Asp) in one of their motifs namely Motif II. Besides they also contain motifs such as motif I, Q-motif, motif VI, motif Ia, Ib, III, IV and V as shown in the diagram below. These motifs bestow properties such as ATP binding and hydrolysis, RNA interaction, remodelling activity etc to these proteins. The consensus sequence of DEAD box family is shown below Copied from (Linder 2006) Regulation and Function of HAGE Both function and regulation of HAGE have not been studied in great detail (Scanlan, Simpson and Old 2004). In normal tissues HAGE expression is regulated by DNA hypermethylation, Histone modifications such as histone aceylation, histone deacylation and histone methylation. However in cancer, there could be many mechanisms of upregulation of HAGE. The most commonly thought mechanism is the demethylation of DNA which leads to HAGE over-expression. (Roman-Gomez, et al. 2007) HAGE could also be induced due to transformation of normal cells during cancer or due to the action of oncogenes. HAGE might also be induced randomly. HAGE may play a role in pre-mRNA splicing, ribosome biogenesis, transcription and initiation of translation. (Rocak and Linder 2004) This project will focus on Head and Neck Cancer. Head and Neck Cancer Head and Neck cancer are the cancers that arise from the upper aerodigestive tract such as nasal cavity, oral cavity, pharynx, larynx and paranasal sinuses. Most of them are of squamous cell carcinoma type of the head and neck and have been given the acronym -SCCHN or HNSCC. (Argiris, et al. 2008). The diagram of the anatomy of the head and neck is illustrated below Copied from (Wu, et al. 2009) More than half a million patients are diagnosed with head and neck cancer every year. Head and Neck cancer in fact accounts for more than 3-10% of the cancers(Gourin and McMains 2005). Smoking, alcohol, chewing of betel leaf with tobacco and areca are the major risk factors for this cancer. Recently, HPV type 16 has been identified as one of the causes for head and neck cancer and account for 40% (Goodger and McGurk 2000) The progression of this tumour is complicated. It progresses from the normal features to hyperplasia, mild dysplasia, moderate dysplasia, severe dysplasia, carcinoma, invasive carcinoma and metastasis. The progression may be caused by due to genetic instabilities such as loss of heterozygosity of chromosome 9p21, inactivation of of p16 and loss of 3p, loss of 18q, inactivation of PTEN, some translocations, 17Beta heterozygosity or TP53 mutation. (Argiris, et al. 2008) Copied from (Argiris, et al. 2008) Interestingly HAGE was found the John van Geest group to be overexpressed in 40% of HNSCC cancers (unpublished data) and although much of its function is now emerging no information exist at the moment regarding the regulation of its expression. However it has been observed that cells left for longer period of time in the incubator had a significantly higher expression of HAGE at the mRNA and protein level. Aim of this project The observation that HAGE was over-expressed in 40% of HNSCC led to hypothesis that cells under stress i.e lack of nutrients, decrease oxygen level, as well as other factors influence HAGE expression. Moreover it has been found that HAGE is also expressed in 20% of Acute Myeloid Leukemia and 50% Chronic Myeloid Leukemia as well as many solid tumours such as HNSCC (Adams, et al. 2002). This suggests that there must be something in common between these 2 very different forms of cancer. CML and solid tumours are known to have a high expression of reactive oxygen species (ROS), therefore it might be possible that ROS induces HAGE expression. Thus this project will focus on the effect of oxidative stress has on HAGE expression. The effect of other stress such as temperature may also be investigated. METHODS Cell Culture The PCI 13 and PCI 30 cell lines would be supplied by Prof E Tatour. These cell lines are specific for Head and Neck cancer. The cells would be grown in RPMI 1640 +10%(v/v) FCS+2mM L-glutamine and incubated at 37oC and 5%C02 atmosphere. Extraction of m-RNA The culture media would be removed and washed with DPBS(Dulbeccos phosphate buffer saline). Then DPBS will be removed followed by the addition of RNA-STAT 60. RNA pellets would be then retrieved and re-suspended in ddH2O. RNA extracted is then quantified using NANODROP 8000 UV spectrophotometer. RNA would be then added in measurement wells of the spectrophotometer. The spectrophotometer would be read at 260 and 280nm and the amount of RNA will be calculated. The RNA concentration is calculated in  µg/ µl before being adjusted to 1 µg/ µl by ddH2O. RNA samples would be then stored at -80oC and used for conducting RT-PCR and RTq-PCR in the future. RT-PCR (Reverse Transcriptase PCR) From the extracted RNA cDNA will be synthesized. 2  µg of RNA sample will be mixed with 1  µl of oligo-dT primers and diluted to 15  µl of ddH20 in an Eppendorf tube. All RNA samples would follow the same process. UNO Thermoblock will be used to heat the tubes to 70 °C for 5 min which allows the primer-RNA annealing. 10  µl of reverse transcriptase mix, which will be prepared by mixing Muloney Murine Leukemia Virus 5-X buffer, dNTPs, RNasin RNAse inhibitor, M-MLV-reverse transcriptase and ddH20. The tubes will be then pre-heated in a water bath at 39.2 °C for 80 min which allows cDNA synthesis. Tubes will be removed and kept again in the UNO-Thermoblock and heated to 95 °C for five minutes which stops the reaction. These tubes would be stored at -20 °C for future use. Real Time qPCR cDNA generated from RT PCR will be used as a template and the reagents used will be (i) 6.25 µl iQ Sybr Green, (ii) 0.5 µl gene specific sense primer (iii) 0.5 µl gene specific anti-sense primer, (iv) 4.75  µl ddH20 and 0.5 µl cDNA template. These reagent mixtures will be added to all tubes for a specific gene. Samples will be usually carried out in duplicate with a negative control that contains the reaction mixture without cDNA. Rotogene 6000 real-time qPCR analyser will be used to carry out RT qPCR. Relative gene expression using 2ΔCT method will be calculated with the help of the expression of housekeeping genes HPRT-1, HSP-27 and HSP-90. The primers which will be used in real time qPCR experiment is given below. These primers are supplied by mwg-Eurofins. The primers have a stock concentration of 100pmol/ µl and will be diluted to a working concentration of 10pmol/ µl. From this working 0.5 µl (5pM) of primers will be used. Total Protein extraction Cells will be grown to 75% confluence in T75 flasks. Cells will be trypsinised, washed and re-suspended in DPBS and these cells will be then counted using trypan blue. Cells will be diluted to 1X106/ml using DPBS and 5 X106 cells would be taken in a 1.5ml eppendorf. Centrifugation will be done to pellet the cells. The supernatant will be discarded and lysis buffer containing a cocktail of RIPA buffer and 10% protease inhibitor will be added to the pellet. The eppendorf tube will be then placed on a tube rotator at 4 °C for 30 min. It will be then kept on ice for 30 min. Cells will be again centrifuged at 14000 RPM for 30 min at 4 °C. Aliquot of the supernatant will be prepared to be stored at -20 °C for future use. Total Protein Assay Total protein assay will be carried out using BioRad Dc protein assay reagents. Series of dilutions (0.2,0.4,0.5,0.8,1.0,1.5,2.0mg/ml) will be created using stock BSA solution with the concentration of 10 mg/ml. Protein extracts and standards would be tested in triplicates and duplicates respectively. Assays will be performed in 96-well round bottom plates. 25 µl and 200  µl of reagent A and B will be added to all the samples and the samples will be incubated at room temperature for an hour. Proteins will be then read at 750nm and their concentrations would be calculated based on the standard values. Western Blotting 30  µl of sample will be loaded into the wells of SDS PAGE gels. 1X tris-glycine-SDS will be used as the running buffer. A known molecular weight ladder will also be run alongside the samples. Initially 70V current will be applied to aid the migration of proteins through the 5% stacking gel. Once the proteins reach the 10% separating gel, 90V current will be applied. After the proteins run through the gel, they will be transferred to the PVDF membrane with the help of liquid transfer. This membrane will be prepared by washing with 10% methanol for 5 seconds, ddH2O for 5 min and transfer buffer for 10 min. Liquid transfer will be carried out using the following steps. 1. Cold transfer buffer will be used to immerse a gel frame. To this gel frame a sponge pre soaked in transfer buffer will be placed Then a filter card, gel, PVDF membrane, another filter card and a second pre soaked buffer sponge will be placed in order starting from the first filter card. Proteins will be transferred with the help of electric current of 100V applied for one hour. After completion, membranes will be cut and treated with different antibodies.10% (w/v) Marvel milk solution will be used to wash the membrane for one hour at room temperature. This washing blocks the non-specific binding sites. The blocking solution will be then discarded and the antibody diluted to 10% (w/v) in Marvel milk solution will be added. This antibody coated membrane will be agitated overnight on a plate rocker at 4 °C. The next day there would be 3, 10 min washes with TSBT(Tris-Buffered Saline-Tween-20). During these washes the membrane vessel will be agitated in plate orbital shaker at room temperature. After completing the washing process, a secondary antibody specific to the primary antibody will be added. The steps for adding the secondary antibody are same as the primary antibody addition except for the fact that no overnight incubation is required and the secondary antibody will be incubated only for one hour while being agitated on the shaker at room temperature. The marker will also be stained using streptavidin-HRP secondary antibody. After performing the above step the membranes will be developed. Membrane development will be performed by placing the membrane in a tray and washing it with ECL reagent. The membrane would be then exposed for a certain period of time using CCD camera. Assay for ROS-DCFDA Stress Test Stock Solution Preparation The stock solution of Hanks Buffered Salt Solution (HBSS)will be prepared according to the manufacturers protocol. DCFDA(2,7-dchlorofluoroscein -diacetate) Assay To test ROS levels DCFDA test will be performed. Before conducting the DCFDA assay, the standardization of optimum concentrations of H2O2 and DCFDA for detecting cell stress should be performed. It is important to note that H2O2 should be added only sub-lethally and should not be added in proportion which may cause cell death. The PCI 13 and 30 cells will be plated out in two 24 well plates. 1ml of each type of cells plus RPM1640 10% FCS media will be added to 8 wells per plate and will be incubated overnight at 37 °C. The media will be removed the next day and increasing concentration of DCFDA will be added to both plates and the cells will be incubated with Tinfoil wrapping to prevent light exposure and incubated at 37oC for 30 min. The cells will be then washed and then cold HBSS will be added. After this step the cells will be stressed with increasing concentration of H2O2 (see diagram below). The cells will then be again wrapped in tin foil and placed on a rocking platform for 15 min. The same method will be followed for treating other wells with different concentrations of DCFDA. Experiments will be performed at least twice for each cell line. H2O2 will be removed after 15 min and cells will be trypsinised with 100microL trypsin and Versene. 800 microL of DPBS will be added to one of the 2 wells an d will be pipetted thoroughly so as to remove the cells from the well surface. This will be then transferred to the other well and then 1ml of solution would be transferred to Flow associated cell cytometry (FACS) tube for analysis. The same procedure will be carried for other sets of wells. DCFDA fluorescence would be measured using Gallios flow cytometer and results would be analysed in Kaluza program. Time Line For The Project During the month of May, all techniques such as Western Blotting, mRNA/protein extraction, Real Time PCR will be learnt. This time is indicated in red colour in the graph below. This will overlap with the time duration, from May to the end of June, during which hydrogen peroxide experiment will be performed as per written in the method section and the expression of HAGE will be monitored at both the mRNA and protein level. Also from the start of June to the end of July repeat experiments will be performed and if time permits, the effect of thermal stress on HAGE expression will also be investigated. This is indicated in the graph below. SUMMARY Cancer Testis Antigens (CTA) are antigens that are expressed in a variety of tumours. They are usually absent in normal tissues with the exception of testis and placenta where they are expressed as self tolerant antigens. Since these antigens have strong immunogenicity and their expression is mostly restricted to tumours, they are ideal targets for cancer immunotherapy. Therefore much research is ongoing for the identification of CTA. Recently helicase antigen HAGE was identified as a CTA and was found to be over-expressed in HSNSCC, AML and CML. Thus there might be a common link between these different types of cancers. Moreover ROS is known to be induced in all these tumours and it may be possible that ROS causes increased expression of HAGE. Thus the aim of this project would be to investigate the effect of oxidative stress on HAGE expression. HAGE expression would be analysed both at the m-RNA and protein level in two cell lines namely PCI 13 and PCI 30 using techniques such as m-RNA extraction, RT PCR, Western Blotting and Protein assay. The ROS level would be evaluated using the DCFDA assay. Since the mechanism of HAGE regulation is unknown, positive result in the project would help in elucidating a mechanism by which HAGE could be regulated.